When isolated from clinical specimens, nondiphtherial Corynebacteria, such as Corynebacterium striatum, Corynebacterium amycolatum. ABSTRACT. We describe an unusual cluster of Corynebacterium striatum infections in 21 patients with chronic obstructive pulmonary disease (COPD) admitted. Objective: To evaluate the clinical significance of and describe factors associated with Corynebacterium striatum infection. Methods: A.

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Amplification and sequencing of genes related to resistance The presence of aminoglycoside modifying enzyme AME genes common in Corynebacterium spp.

Corynebacterium striatum Bacteremia Associated with a Catheter-Related Blood Stream Infection

However, the role of these bacteria in clinical disease is now more clearly established. PFGE patterns and antibiotic resistance profiles of the 63 C. Although an implantable cardioverter defibrillator CRT-D, Cardiac Resynchronization Therapy-Defibrillationwith biventricular pacing function, was replaced with PM for severe left ventricular functional decline, on day 12 of admission, an intra-aortic balloon pump IABP was also inserted because of multiple organ failure. Agricultural and Biological Chemistry.

Clinical and Laboratory Standards Institute As expected, the 10 C. Therefore, in this case, appropriate antibiotics could not be judged in vivo. Cystitis and haematuria due to Corynebacterium striatum.

Case Reports in Infectious Diseases

Acquired antibiotic resistance genes: This page was last edited on 13 Decemberat Cortnebacterium of a case with polymicrobial endocarditis related to multiresistant strains. Corynebacterium species are widely distributed in the environment and in the microbiota of humans and animals.

Bergey’s Manual of Systematic Bacteriology 2nd ed.

The mef A-E gene was not found in any strain tested. A variety of Gram-positive bacteria carry mobile mef genes. From the 24 clindamycin-resistant isolates 22 were positive for the gene erm X and 10 out of 22 were also erm B -positive.


One of the most serious problems related to treatment of the infections caused by C. Although patients with implanted CRT-D may develop infectious endocarditis, obvious vegetation was sstriatum observed on echocardiography in cotynebacterium cases [ 11 ].

Isolates were classified as resistant, intermediate, or susceptible, according to criteria defined by CLSI One third of our C.

Transpl Infect Dis ;5: Three strains had a mutation at amino acid codon Ser that changes this amino acid for Tyr or Phe. No bacteria species could be identified at this time. Clinical microbiology of coryneform bacteria. Corynebacterium diphtheriae and nondiphtherial Corynebacteriacollectively referred to as diphtheroids.

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Notes Competing Interests The authors declare that they have no competing interests. Unwanted side reactions such as threonine and asparagine production can occur if a buildup of intermediates occurs, so scientists have developed mutant strains of C.

Exposure to fluoroquinolones selects for spontaneous mutants in large bacterial populations, including those that colonize the skin and mucous membranes such as corynebacteria. Corynebacterium striatum is recognized as a true pathogen when isolated in several samples from sterile body sites or from indwelling medical devices 12. A year-old woman visited our emergency department because of exertional dyspnea due to severe left ventricular functional failure.

PCR reactions were performed as previously described Structure, Function, and Genetics. Thus, the patient was diagnosed with a C. Bergey’s Manual of Systematic Bacteriology. Multidrug-resistant Corynebacterium striatum bacteremia: Abstract A year-old woman visited our emergency department because of exertional dyspnea due to severe left ventricular functional failure. This would eventually lead this strain to become a secondary colonizer in immunocompromised hosts [ 8 ].

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As the same type of bacteria was detected by the catheter tip culture, the cervical catheter was withdrawn during the hemodialysis, as it was presumed to be the port of entry in this case. Comparative analysis of corynebacterial genomes has led to the identification of several conserved signature indels which are unique to the genus.

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Consideration of whether an isolate represents infection, colonization, or contamination is based upon clinical assessment.

Susceptibility testing of C. Pulsed field gel electrophoresis: Bacteria classification phyla and orders. Corynebacterium striatum infecting a malignant cutaneous lesion: Multidrug-resistant Corynebacterium striatum pneumonia in a heart transplant recipient. The presence of aminoglycoside modifying enzyme AME genes common in Corynebacterium spp.

Although initial studies indicated that C.

In fourteen of the 21 fluoroquinolone-resistant C. Clonal multidrug-resistant Corynebacterium striatum strains, Italy. Daptomycin has also been proven to be active against C. Sixty-three out of the 90 strains were identified as putative C. Enzymatic inactivation of the antibiotic molecule is the most prevalent in the clinical setting. Necrotizing fasciitis of lower limb by Corynebacterium Striatum in a HbsAg positive patient.

Corynebacteria grow slowly, even on enriched media. The Corynebacteria are divided into two groups: