Autosomal dominant Emery-Dreifuss muscular dystrophy Summary. This disease is described under Emery-Dreifuss muscular dystrophy. Emery-Dreifuss muscular dystrophy, characterized by the clinical triad of joint contractures, muscle weakness and cardiac involvement. A distrofia muscular de Emery Dreifus tipo 1 (DMED1) é uma doença familiar, com transmissão recessiva ligada ao X, resultante da mutação de uma proteína.

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Alport syndrome Dent’s disease X-linked nephrogenic diabetes insipidus. There were no fasciculations.

Orphanet: Distrofia muscular de Emery Dreifuss, autossómica dominante EDMD2

Bilateral motor deficit of the quadriceps deteriorated progressively, without involvement of other muscles. The neurological examination showed general amyotrophy and weakness against slight resistance of deltoids, biceps, and triceps, with good strength of hand muscles. Immunohistochemical staining using an emerin antibody showed df of the protein in a fragment of muscle tissue and genetic study identified a mutation associated with EDMD1.

Hence, a pacemaker placement was suggested. Diagnostic suspicion is based on these clinical and electrocardiographic findings, which can be confirmed by muscle biopsy and genetic study. The electrocardiogram revealed atrial fibrillation with controlled ventricular rate, but no other dishrofia.

Therefore, it should be very interesting to consider the possibility of the existence of two distinctive genetic disorders, resulting from different electromyographic and biopsy patterns as reported in literature, but giving rise to similar phenotypic expressions.

Bethlem J, Knobbout CE. Additional information Further information on this disease Classification s 4 Gene s 4 Clinical signs and symptoms Other website s 2. Emery Dreifuss muscular dystrophy”. Emery-Dreifuss muscular dystrophy 1, X-linked.


A number of families have been reported which fit an autossomal dominant pattern of inheritance. At age 26 he developed tachycardia episodes.

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Permanent pacemaker implantation is recommended musculwr all patients with evidence of conduction tissue disease, 9 as it reduces the risk of sudden death, 11,14 although there have been reports of sudden death even after pacemaker implantation. Keratinopathy keratosiskeratodermahyperkeratosis: These same changes were also observed in fibroblasts from patients with other genetic forms of EDMD, indicating that loss of nesprin is a characteristic of all forms of EDMD.

Subscribe to our Newsletter. Via fluorescent in-situ hybridization the gene is located at chromosome 14q23 [13].

Services on Disrtofia Journal. She had marked restriction of neck flexion beginning at age 11 years, with contractures of the posterior cervical muscles, elbows, and ankles.

There were no significant morphological findings in the other organs. Criteria to establish diagnosis of EDMD have been recently postulated 2: The Distrofiw is a monthly publication with high standards of quality in terms muscylar scientific content and production.

The Portuguese Journal of Cardiology, the official journal of the Portuguese Society of Cardiology, was founded in with the aim of keeping Portuguese cardiologists informed through the publication of scientific articles on areas such as arrhythmology and electrophysiology, cardiovascular surgery, intensive care, coronary artery disease, cardiovascular imaging, hypertension, heart failure and cardiovascular prevention.

We describe the case of a young male, aged 16, with first-degree atrioventricular AV block and limited extension of both forearms.

Emery–Dreifuss muscular dystrophy – Wikipedia

The only relevant family history was the premature death of a maternal aunt, probably due to neuromuscular disease. He was subsequently referred to our hospital for a neuromuscular disease consultation. While female carriers do not develop musculoskeletal symptoms, they can have conduction disorders, and there have been some reports of sudden death. Its functions are poorly understood, but it is assumed to play a crucial role in regulating gene expression and maintaining nuclear structure.


In the third or fourth decade, upper-limb muscles gradually became affected as well. Hypertrophic cardiomyopathy 7, 2 Nemaline myopathy 4, 5.

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years. Evolution of a hereditary cardiac conduction and muscle disorder: Some other sporadic cases, including in women, have been reported 2,3,8.

An autosomal dominant dystrophy with humeropelvic distribution and cardiomyopathy. The limb-girdle muscles were underdeveloped and weak. OMIM is intended for use primarily by physicians dde other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. A newly recognized autosomal dominant limb girdle muscular dystrophy with cardiac involvement. Study of his brother, aged 21, also established a diagnosis of EDMD1.

Emery-Dreifuss muscular dystrophy 6, X-linked. Most of the LMNA mutations that cause this condition result in the production of an altered version of these proteins.