Transplantation. Jul 27;66(2) Uricosuric effect of the angiotensin II receptor antagonist losartan in heart transplant recipients. Minghelli G(1). This agent promotes uric acid excretion via effects on the organic anion transport The AIIA losartan also produces a uricosuric effect in healthy volunteers. Uricosuric medications (drugs) are substances that increase the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma. In general, this effect is achieved by action on the proximal tubule of the the uricosurics benzbromarone and losartan had no effect, suggesting these drugs act.

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In conclusion, losartan is the only ARB that has consistently demonstrated a significant reduction in serum uric acid levels, although the significance of impacting clinical outcomes remains unknown.

Conclusion This review explored evidence for ARBs and the reduction of serum uric acid levels and increased fractional excretion of uric acid. Bibliographies of relevant articles were lossartan for additional citations.

Ann Rheum Dis Effect of losartan on renal excretion of urate in a hypouricemic hypertensive patient no. Although serum urate levels are also controlled by the production of uric acid in the liver, losartan and its active metabolite E have been reported to exert no inhibitory effects on the xanthine oxidase activity in an in vitro experiment.

In borderline cases, enough water to produce 2 liters of urine per day may be sufficient to permit use of an uricosuric drug.

The URAT1 inhibitor did not modify urate excretion in the URAT1-deficient patients with or without impaired renal function, indicating impaired renal function associated with idiopathic renal hypouricemia did not affect the results of the URAT1 inhibitor loading test. While utilized for similar indications, the available ARBs differ widely in their chemical lodartan, which correlate to various differences in their pharmacodynamic and pharmacokinetic effects.

Uricosuric effect of losartan in patients with renal transplants.

The impact of serum uric acid on cardiovascular outcomes in the LIFE study. J Pharmacol Exp Ther To estimate the validity of a single period for the clearance test, we conducted probenecid and losartan loading tests in hypertensive case no. In general, this effect is achieved by action on the proximal tubule of the kidney. Before and after 1-month treatment, the serum concentration of urate Sur and creatinine Scrand the clearance value of urate Cur and creatinine Ccr were determined.


Uromodulin in a pathway between decreased renal urate excretion and albuminuria. Many of the studies also lacked a control group [ Rayner et al.

Related articles Gout hypertension losartan uric acid valsartan. This review explored the available literature for the urate-lowering effects of ARBs. Khan and colleagues conducted a randomized, open-label, prospective, comparative study in which 60 patients with hyperuricemia ranging from 7.

URAT1 serves as a urate—anion exchanger in the proximal tubule of the kidney and is a key target for uricosuric wffect [ Choi et al. From Wikipedia, the free encyclopedia.


All the procedures carried out in this study were in accordance with the Helsinki Declaration of as revised in lsartan Upon review of the three studies which looked at the uricosuric effects of candesartan and irbesartan, there was no significant benefit with use of these agents [ Dang et al. From baseline, fenofibrate reduced serum uric acid levels from 7. There were no significant changes in biochemical parameters such as liver enzymes, serum levels of creatinine, sodium and bicarbonate.

It is unclear whether alternative ARBs other than those studied in this review have the same binding potential as losartan.

Effetc exclusive offers and updates from Oxford Academic. This is thought to occur by inhibition of the URAT1 anion exchanger responsible for the reabsorption of filtered urate, which is located in the proximal tubule of the kidney [ Choi et al. In a population-based study from the United Kingdom inresults showed that the prevalence of gout has increased by Neutral effect of valsartan on serum uric acid and renal function tests.

Uricosuric effect of losartan in patients with renal transplants.

After the patient sat for 5 min, BP was measured three times at 1—2- min intervals, and the mean value was taken as the average BP for that visit. We demonstrated that candesartan did not increase urate excretion 2 h after its administration, or after 1 month of treatment. Both drugs were well tolerated; however, there was one serious adverse effect noted in the study that was not described by the authors [ Rayner et al. This adverse effect was not expected, although this raises an important concern with chronically elevated serum uric acid levels precipitating gout attacks.

The effect of angiotensin II receptor blockers on hyperuricemia

National Center for Biotechnology InformationU. This study was a prospective, randomized, double-blind, crossover study design. Xanthine oxidase inhibition as a potential treatment for aortic stiffness in hypertension.


Uric acid in childhood essential hypertension. Shahinfar and colleagues conducted a double-blind, placebo-controlled, parallel study with 63 patients to explore the safety and efficacy of losartan in individuals with thiazide-induced hyperuricemia [ Shahinfar et al. Effect of the angiotensin II receptor antagonist losartan on uric acid and oxypurine metabolism in healthy subjects. Clinical and molecular analysis of patients with renal hypouricemia in Japan—influence of URAT1 gene on urinary urate excretion.

The angiotensin receptor blocker losartan inhibited urate transporter 1 URAT1 according to in vitro experiments. While this is occasionally exploitable to good effect see oseltamivirassessment of drug interactions is very important when using uricosuric drugs in the presence of other medications.

These findings suggested that losartan inhibited URAT1 and thereby it lowered Sur levels in hypertensive patients. Future studies would be needed to determine if this is the case.

Because changes in renal excretion of urate induced by angiotensin receptor blockers might be influenced by renal adaptation during their administration, we reexamined the losarta effects of candesartan before lsartan 2 h after its administration on renal excretion of urate. Uric uricoshric stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system. First-line urate-lowering agents are xanthine oxidase inhibitors such as allopurinol and febuxostat.

Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule. A month after the benzbromarone test, the patients received 50 mg oral losartan and the same measurements were taken. The phase before the administration of the drug consisted of uricosurkc single-clearance period of 30 min.

This article has been cited by other articles in PMC. In this study, we first confirmed the uricosuric action of losartan in hypertensive patients in comparison with candesartan.

Individuals with a history of secondary hypertension, history of gout and renal lithiasis in the last 2 years, history of malignant hypertension, history of CVA within the last 2 years and history of cardiac arrhythmia were all excluded from this study. Pak J Pharm Sci We demonstrated that losartan at a clinical dose level failed to induce uricosuria in URAT1-deficient hypouricemia patients.